Apigenin Prevents Acetaminophen-Induced Liver Injury by Activating the SIRT1 Pathway

• Main Authors: Licong Zhao (Author), Jiaqi Zhang (Author), Cheng Hu (Author), Tao Wang (Author), Juan Lu (Author), Chenqu Wu (Author), Long Chen (Author), Mingming Jin (Author), Guang Ji (Author), Qin Cao (Author), Yuanye Jiang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acetaminophen (APAP) overdose is the main cause of acute liver failure. Apigenin (API) is a natural dietary flavonol with high antioxidant capacity. Herein, we investigated protection by API against APAP-induced liver injury in mice, and explored the potential mechanism. Cell viability assays and mi...