Conjugation with Tris Decreases the Risk of Ketoprofen-Induced Mucosal Damage and Reduces Inflammation-Associated Methane Production in a Rat Model of Colitis

• Main Authors: Melinda Ugocsai (Author), Anett Bársony (Author), Réka Anna Varga (Author), Ámos Gajda (Author), Noémi Vida (Author), Norbert Lajkó (Author), Benedek Rónaszéki (Author), Gábor Tóth (Author), Mihály Boros (Author), Dániel Érces (Author), Gabriella Varga (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have designed a new compound from the non-steroidal anti-inflammatory drug (NSAID) ketoprofen (Ket) and 2-amino-2-(hydroxymethyl)-1,3-propanediol (Tris) precursors, with the aim to reduce the gastrointestinal (GI) side effects of NSAID therapies. We investigated mucosal reactions in a standard ra...