In vivo antitumor effects of carboxymethyl chitosan-conjugated triptolide after oral administration

• Main Authors: Huahui Zeng (Author), Xin Zhu (Author), Qikang Tian (Author), Yinyin Yan (Author), Lan Zhang (Author), Min Yan (Author), Ruiqin Li (Author), Xiaofang Li (Author), Guoqiang Wang (Author), Jinlian Ma (Author), Yufang Su (Author), Xiangbo Zhang (Author), Linyu Ma (Author), Zhenqiang Zhang (Author), Xiangxiang Wu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of this study is to evaluate in vitro and in vivo antitumor efficacy and subacute toxicity of triptolide (TP) prodrug, a conjugate between TP and carboxymethyl chitosan (CC). The CCTP conjugate contained 4∼ wt % TP and displayed excellent aqueous solubility (5 mg/mL) as compared to the n...