Recent progress and challenges in screening and characterization of UGT1A1 inhibitors

• Main Authors: Xia Lv (Author), Yangliu Xia (Author), Moshe Finel (Author), Jingjing Wu (Author), Guangbo Ge (Author), Ling Yang (Author)
• Format: Book
• Published: Elsevier, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Uridine-diphosphate glucuronosyltransferase 1A1 (UGT1A1) is an important conjugative enzyme in mammals that is responsible for the conjugation and detoxification of both endogenous and xenobiotic compounds. Strong inhibition of UGT1A1 may trigger adverse drug/herb-drug interactions, or result in met...