Modulation of the IL-6-Signaling Pathway in Liver Cells by miRNAs Targeting gp130, JAK1, and/or STAT3

• Main Authors: Florence A. Servais (Author), Mélanie Kirchmeyer (Author), Matthias Hamdorf (Author), Nadège W.E. Minoungou (Author), Stefan Rose-John (Author), Stephanie Kreis (Author), Claude Haan (Author), Iris Behrmann (Author)
• Format: Book
• Published: Elsevier, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interleukin-6 (IL-6)-type cytokines share the common receptor glycoprotein 130 (gp130), which activates a signaling cascade involving Janus kinases (JAKs) and signal transducer and activator of transcription (STAT) transcription factors. IL-6 and/or its signaling pathway is often deregulated in dise...