GC-NICI-MS analysis of acetazolamide and other sulfonamide (R-SO2-NH2) drugs as pentafluorobenzyl derivatives [R-SO2-N(PFB)2] and quantification of pharmacological acetazolamide in human urine

Acetazolamide (molecular mass (MM), 222) belongs to the class of sulfonamides (R-SO2-NH2) and is one of the strongest pharmacological inhibitors of carbonic anhydrase activity. Acetazolamide is excreted unchanged in the urine. Here, we report on the development, validation and biomedical application...

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Main Authors: Olga Begou (Author), Kathrin Drabert (Author), Georgios Theodoridis (Author), Dimitrios Tsikas (Author)
Format: Book
Published: Elsevier, 2020-02-01T00:00:00Z.
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