Mechanical Stress-Induced IGF-1 Facilitates col-I and col-III Synthesis via the IGF-1R/AKT/mTORC1 Signaling Pathway

• Main Authors: Bin Yan (Author), Canjun Zeng (Author), Yuhui Chen (Author), Minjun Huang (Author), Na Yao (Author), Jie Zhang (Author), Bo Yan (Author), Jiajun Tang (Author), Liang Wang (Author), Zhongmin Zhang (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mechanical stress promotes human ligamentum flavum cells (LFCs) to synthesize multitype collagens, leading to ligamentum flavum hypertrophy (LFH). However, the mechanism of mechanical stress in the formation of collagen remains unclear. Therefore, we investigated the relationship between mechanical...