Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12

Post-SELEX modification of DNA aptamers is an established strategy to improve their affinity or inhibitory characteristics. In this study, we examined the possibility of increasing the recognition interface between the thrombin-binding aptamer HD1 (TBA) and thrombin by adding a chemically modified s...

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Bibliographic Details
Main Authors: Igor Smirnov (Author), Natalia Kolganova (Author), Romualdo Troisi (Author), Filomena Sica (Author), Edward Timofeev (Author)
Format: Book
Published: Elsevier, 2021-03-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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