Design, Synthesis, Molecular Modeling, and Anticancer Evaluation of New VEGFR-2 Inhibitors Based on the Indolin-2-One Scaffold

• Main Authors: Mohamed A. Abdelgawad (Author), Alaa M. Hayallah (Author), Syed Nasir Abbas Bukhari (Author), Arafa Musa (Author), Mohammed Elmowafy (Author), Hamdy M. Abdel-Rahman (Author), Mohammed K. Abd El-Gaber (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new series of indoline-2-one derivatives was designed and synthesized based on the essential pharmacophoric features of VEGFR-2 inhibitors. Anti-proliferative activities were assessed for all derivatives against breast (MCF-7) and liver (HepG2) cancer cell lines, using sunitinib as a reference age...