Comprehensive behavioral analysis of heterozygous Syngap1 knockout mice

• Main Authors: Ryuichi Nakajima (Author), Keizo Takao (Author), Satoko Hattori (Author), Hirotaka Shoji (Author), Noboru H. Komiyama (Author), Seth G. N. Grant (Author), Tsuyoshi Miyakawa (Author)
• Format: Book
• Published: Wiley, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Aims Synaptic Ras GTPase‐activating protein 1 (SYNGAP1) regulates synaptic plasticity through AMPA receptor trafficking. SYNGAP1 mutations have been found in human patients with intellectual disability (ID) and autism spectrum disorder (ASD). Almost every individual with SYNGAP1‐related ID...