Distinguishing the Concentration- vs. Bioaccumulation-Dependent Immunological and Metabolic Effects of Clofazimine

The antimycobacterial drug clofazimine (CFZ) is used as a single agent at high doses, to suppress the exaggerated inflammation associated with leprosy. Paradoxically, increasing doses of CFZ leads to bioaccumulation of CFZ in the spleen and other organs under physiologically relevant dosing regimens...

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Main Authors: Andrew R. Willmer (Author), Jennifer Diaz-Espinosa (Author), Austin Zhou (Author), Kathleen A. Stringer (Author), Gus R. Rosania (Author)
Format: Book
Published: MDPI AG, 2023-09-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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