Visualizing the Potential Impairment of Polymyxin B to Central Nervous System Through MR Susceptibility-Weighted Imaging

• Main Authors: Ni Zhang (Author), Lichong Zhu (Author), Qiuhong Ouyang (Author), Saisai Yue (Author), Yichun Huang (Author), Shuang Qu (Author), Runwei Li (Author), Yuanyuan Qiao (Author), Man Xu (Author), Fangfei He (Author), Bin Zhao (Author), Lai Wei (Author), Xiaoai Wu (Author), Peisen Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polymyxin B (PMB) exert bactericidal effects on the cell wall of Gram-negative bacteria, leading to changes in the permeability of the cytoplasmic membrane and resulting in cell death, which is sensitive to the multi-resistant Gram-negative bacteria. However, the severe toxicity and adverse side eff...