A drug repurposing screen for whipworms informed by comparative genomics.

• Main Authors: Avril Coghlan (Author), Frederick A Partridge (Author), María Adelaida Duque-Correa (Author), Gabriel Rinaldi (Author), Simon Clare (Author), Lisa Seymour (Author), Cordelia Brandt (Author), Tapoka T Mkandawire (Author), Catherine McCarthy (Author), Nancy Holroyd (Author), Marina Nick (Author), Anwen E Brown (Author), Sirapat Tonitiwong (Author), David B Sattelle (Author), Matthew Berriman (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura. Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy. We have investigated whether drugs approved for other human diseases could be repurposed as novel ant...