Applicability of MDR1 Overexpressing Abcb1KO-MDCKII Cell Lines for Investigating In Vitro Species Differences and Brain Penetration Prediction

Applicability of MDR1 Overexpressing Abcb1KO-MDCKII Cell Lines for Investigating In Vitro Species Differences and Brain Penetration Prediction

Implementing the 3R initiative to reduce animal experiments in brain penetration prediction for CNS-targeting drugs requires more predictive in vitro and in silico models. However, animal studies are still indispensable to obtaining brain concentration and determining the prediction performance of i...

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Main Authors: Emőke Sóskuti (Author), Nóra Szilvásy (Author), Csilla Temesszentandrási-Ambrus (Author), Zoltán Urbán (Author), Olivér Csíkvári (Author), Zoltán Szabó (Author), Gábor Kecskeméti (Author), Éva Pusztai (Author), Zsuzsanna Gáborik (Author)
Format: Book
Published: MDPI AG, 2024-05-01T00:00:00Z.
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