Caffeine reduces oxidative stress to protect against hyperoxia-induced lung injury via the adenosine A2A receptor/cAMP/PKA/Src/ERK1/2/p38MAPK pathway

• Main Authors: Xijuan Wang (Author), Shuai Lv (Author), Jianwei Sun (Author), Meihui Zhang (Author), Lei Zhang (Author), Yan Sun (Author), Ziyan Zhao (Author), Dandan Wang (Author), Xinjing Zhao (Author), Jiajie Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Caffeine has been shown to reduce the incidence of bronchopulmonary dysplasia (BPD). To investigate the protective mechanism of caffeine in a hyperoxia-based cell model of BPD in vitro.Methods: Type II alveolar epithelial cells (AECs II) were isolated and randomly divided into 6 groups:...