Transient Receptor Potential Melastatin 7 (TRPM7) Contributes to H2O2-Induced Cardiac Fibrosis via Mediating Ca2+ Influx and Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Activation in Cardiac Fibroblasts

• Main Authors: Jin-Lei Guo (Author), Yang Yu (Author), Yan-Yan Jia (Author), Yun-Zi Ma (Author), Bo-Yu Zhang (Author), Pei-Qing Liu (Author), Shao-Rui Chen (Author), Jian-Min Jiang (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Transient receptor potential melastatin 7 (TRPM7), a Ca2+-nonselective cation channel, plays a key role in the pathophysiological response of multiple cell types. However, the role of TRPM7 channels in hydrogen peroxide (H2O2)-induced cardiac fibrosis remains unclear. This study aimed to...