Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase

• मुख्य लेखकों: Elisa Rojas-Prats (लेखक), Loreto Martinez-Gonzalez (लेखक), Carmen Gil (लेखक), David Ramírez (लेखक), Ana Martinez (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

AbstractCell division cycle 7 kinase (CDC7) has been found overexpressed in many cancer cell lines being also one of the kinases involved in the nuclear protein TDP-43 phosphorylation in vivo. Thus, inhibitors of CDC7 are emerging drug candidates for the treatment of oncological and neurodegenerativ...