Microbiota Imbalance Contributes to COPD Deterioration by Enhancing IL-17a Production via miR-122 and miR-30a

• Main Authors: Ke Zhu (Author), Sijing Zhou (Author), Aiqun Xu (Author), Li Sun (Author), Min Li (Author), Huihui Jiang (Author), Binbin Zhang (Author), Daxiong Zeng (Author), Guanghe Fei (Author), Ran Wang (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The changes of microbiota in lungs could change interleukin-17a (IL-17a) expression by altering microRNAs (miRNAs) profile, thus contributing to the pathogenesis of chronic obstructive pulmonary disease (COPD). In this study, we aimed to study molecular mechanisms' underlying effect of microbio...