Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors

• Main Authors: Ezio Bettini (Author), Stephen M. Stahl (Author), Sara De Martin (Author), Andrea Mattarei (Author), Jacopo Sgrignani (Author), Corrado Carignani (Author), Selena Nola (Author), Patrizia Locatelli (Author), Marco Pappagallo (Author), Charles E. Inturrisi (Author), Francesco Bifari (Author), Andrea Cavalli (Author), Andrea Alimonti (Author), Luca Pani (Author), Maurizio Fava (Author), Sergio Traversa (Author), Franco Folli (Author), Paolo L. Manfredi (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Excessive Ca²⁺ currents via N-methyl-D-aspartate receptors (NMDARs) have been implicated in many disorders. Uncompetitive NMDAR channel blockers are an emerging class of drugs in clinical use for major depressive disorder (MDD) and other neuropsychiatric diseases. The pharmaco...