Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors

• Автори: Ezio Bettini (Автор), Stephen M. Stahl (Автор), Sara De Martin (Автор), Andrea Mattarei (Автор), Jacopo Sgrignani (Автор), Corrado Carignani (Автор), Selena Nola (Автор), Patrizia Locatelli (Автор), Marco Pappagallo (Автор), Charles E. Inturrisi (Автор), Francesco Bifari (Автор), Andrea Cavalli (Автор), Andrea Alimonti (Автор), Luca Pani (Автор), Maurizio Fava (Автор), Sergio Traversa (Автор), Franco Folli (Автор), Paolo L. Manfredi (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2022-08-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Excessive Ca²⁺ currents via N-methyl-D-aspartate receptors (NMDARs) have been implicated in many disorders. Uncompetitive NMDAR channel blockers are an emerging class of drugs in clinical use for major depressive disorder (MDD) and other neuropsychiatric diseases. The pharmaco...