8-Substituted Triazolobenzodiazepines: In Vitro and In Vivo Pharmacology in Relation to Structural Docking at the α1 Subunit-Containing GABAA Receptor

8-Substituted Triazolobenzodiazepines: In Vitro and In Vivo Pharmacology in Relation to Structural Docking at the α1 Subunit-Containing GABAA Receptor

In order to develop improved anxiolytic drugs, 8-substituted analogs of triazolam were synthesized in an effort to discover compounds with selectivity for α2/α3 subunit-containing GABAA subtypes. Two compounds in this series, XLi-JY-DMH (6-(2-chlorophenyl)-8-ethynyl-1-methyl-4H-benzo [f][1,2,4]triaz...

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Main Authors: Lalit K. Golani (Author), Donna M. Platt (Author), Daniela Rüedi-Bettschen (Author), Chitra Edwanker (Author), Shenming Huang (Author), Michael M. Poe (Author), Roman Furtmüller (Author), Werner Sieghart (Author), James M. Cook (Author), James K. Rowlett (Author)
Format: Book
Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
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