8-Substituted Triazolobenzodiazepines: In Vitro and In Vivo Pharmacology in Relation to Structural Docking at the α1 Subunit-Containing GABAA Receptor

• Auteurs principaux: Lalit K. Golani (Auteur), Donna M. Platt (Auteur), Daniela Rüedi-Bettschen (Auteur), Chitra Edwanker (Auteur), Shenming Huang (Auteur), Michael M. Poe (Auteur), Roman Furtmüller (Auteur), Werner Sieghart (Auteur), James M. Cook (Auteur), James K. Rowlett (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

In order to develop improved anxiolytic drugs, 8-substituted analogs of triazolam were synthesized in an effort to discover compounds with selectivity for α2/α3 subunit-containing GABAA subtypes. Two compounds in this series, XLi-JY-DMH (6-(2-chlorophenyl)-8-ethynyl-1-methyl-4H-benzo [f][1,2,4]triaz...