Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels

• Main Authors: Ferrer-Montiel Antonio (Author), Fernández-Ballester Gregorio (Author), Pertusa María (Author), Malkia Annika (Author), Viana Félix (Author)
• Format: Book
• Published: SAGE Publishing, 2009-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>TRPM8 is a non-selective cation channel that belongs to the melastatin subfamily of the transient receptor potential (TRP) ion channels. TRPM8 is activated by voltage, cold and cooling compounds such as menthol. Despite its essential...