Heterogeneity and versatility of the extracellular matrix during the transition from pleomorphic adenoma to carcinoma ex pleomorphic adenoma: cumulative findings from basic research and new insights

• Main Authors: João Figueira Scarini (Author), Reydson Alcides de Lima-Souza (Author), Luccas Lavareze (Author), Maria Clara Falcão Ribeiro de Assis (Author), Ingrid Iara Damas (Author), Albina Altemani (Author), Erika Said Abu Egal (Author), Jean Nunes dos Santos (Author), Ibrahim Olajide Bello (Author), Fernanda Viviane Mariano (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pleomorphic adenoma (PA) is the most common salivary gland tumor, accounting for 50%-60% of these neoplasms. If untreated, 6.2% of PA may undergo malignant transformation to carcinoma ex-pleomorphic adenoma (CXPA). CXPA is a rare and aggressive malignant tumor, whose prevalence represents approximat...