Allosteric Modulation of Beta1 Integrin Function Induces Lung Tissue Repair

• Main Authors: Rehab AlJamal-Naylor (Author), Linda Wilson (Author), Susan McIntyre (Author), Fiona Rossi (Author), Beth Harrison (Author), Mark Marsden (Author), David J. Harrison (Author)
• Format: Book
• Published: Hindawi Limited, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cellular cytoskeleton, adhesion receptors, extracellular matrix composition, and their spatial distribution are together fundamental in a cell's balanced mechanical sensing of its environment. We show that, in lung injury, extracellular matrix-integrin interactions are altered and this lead...