ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model

• Main Authors: Keisuke Kitakaze (Author), Miho Oyadomari (Author), Jun Zhang (Author), Yoshimasa Hamada (Author), Yasuhiro Takenouchi (Author), Kazuhito Tsuboi (Author), Mai Inagaki (Author), Masanori Tachikawa (Author), Yoshio Fujitani (Author), Yasuo Okamoto (Author), Seiichi Oyadomari (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Activating transcription factor 4 (ATF4) is a transcriptional regulator of the unfolded protein response and integrated stress response (ISR) that promote the restoration of normal endoplasmic reticulum (ER) function. Previous reports demonstrated that dysregulation of the ISR led to deve...