Ivacaftor pharmacokinetics and lymphatic transport after enteral administration in rats

• Main Authors: Jiří Pozniak (Author), Pavel Ryšánek (Author), David Smrčka (Author), Petr Kozlík (Author), Tomáš Křížek (Author), Jaroslava Šmardová (Author), Anežka Nováková (Author), Debanjan Das (Author), Daniel Bobek (Author), Mahak Arora (Author), Jiří Hofmann (Author), Tereza Doušová (Author), Martin Šíma (Author), Ondřej Slanař (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Ivacaftor is a modern drug used in the treatment of cystic fibrosis. It is highly lipophilic and exhibits a strong positive food effect. These characteristics can be potentially connected to a pronounced lymphatic transport after oral administration.Methods: A series of studies was condu...