Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

• Príomhchruthaitheoirí: Maria Lazaridou (Údar), Evi Christodoulou (Údar), Maria Nerantzaki (Údar), Margaritis Kostoglou (Údar), Dimitra A. Lambropoulou (Údar), Angeliki Katsarou (Údar), Kostas Pantopoulos (Údar), Dimitrios N. Bikiaris (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: MDPI AG, 2020-03-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...