Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

• المؤلفون الرئيسيون: Maria Lazaridou (مؤلف), Evi Christodoulou (مؤلف), Maria Nerantzaki (مؤلف), Margaritis Kostoglou (مؤلف), Dimitra A. Lambropoulou (مؤلف), Angeliki Katsarou (مؤلف), Kostas Pantopoulos (مؤلف), Dimitrios N. Bikiaris (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2020-03-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...