Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

• Prif Awduron: Maria Lazaridou (Awdur), Evi Christodoulou (Awdur), Maria Nerantzaki (Awdur), Margaritis Kostoglou (Awdur), Dimitra A. Lambropoulou (Awdur), Angeliki Katsarou (Awdur), Kostas Pantopoulos (Awdur), Dimitrios N. Bikiaris (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2020-03-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...