Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

• Κύριοι συγγραφείς: Maria Lazaridou (Συγγραφέας), Evi Christodoulou (Συγγραφέας), Maria Nerantzaki (Συγγραφέας), Margaritis Kostoglou (Συγγραφέας), Dimitra A. Lambropoulou (Συγγραφέας), Angeliki Katsarou (Συγγραφέας), Kostas Pantopoulos (Συγγραφέας), Dimitrios N. Bikiaris (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2020-03-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...