Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

• Egile Nagusiak: Maria Lazaridou (Egilea), Evi Christodoulou (Egilea), Maria Nerantzaki (Egilea), Margaritis Kostoglou (Egilea), Dimitra A. Lambropoulou (Egilea), Angeliki Katsarou (Egilea), Kostas Pantopoulos (Egilea), Dimitrios N. Bikiaris (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2020-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...