Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

• Päätekijät: Maria Lazaridou (Tekijä), Evi Christodoulou (Tekijä), Maria Nerantzaki (Tekijä), Margaritis Kostoglou (Tekijä), Dimitra A. Lambropoulou (Tekijä), Angeliki Katsarou (Tekijä), Kostas Pantopoulos (Tekijä), Dimitrios N. Bikiaris (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2020-03-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...