Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

• Auteurs principaux: Maria Lazaridou (Auteur), Evi Christodoulou (Auteur), Maria Nerantzaki (Auteur), Margaritis Kostoglou (Auteur), Dimitra A. Lambropoulou (Auteur), Angeliki Katsarou (Auteur), Kostas Pantopoulos (Auteur), Dimitrios N. Bikiaris (Auteur)
• Format: Livre
• Publié: MDPI AG, 2020-03-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...