Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

• Main Authors: Maria Lazaridou (Author), Evi Christodoulou (Author), Maria Nerantzaki (Author), Margaritis Kostoglou (Author), Dimitra A. Lambropoulou (Author), Angeliki Katsarou (Author), Kostas Pantopoulos (Author), Dimitrios N. Bikiaris (Author)
• Formato: Libro
• Publicado: MDPI AG, 2020-03-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...