Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

• 主要な著者: Maria Lazaridou (著者), Evi Christodoulou (著者), Maria Nerantzaki (著者), Margaritis Kostoglou (著者), Dimitra A. Lambropoulou (著者), Angeliki Katsarou (著者), Kostas Pantopoulos (著者), Dimitrios N. Bikiaris (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2020-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...