Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

• Үндсэн зохиолчид: Maria Lazaridou (Зохиогч), Evi Christodoulou (Зохиогч), Maria Nerantzaki (Зохиогч), Margaritis Kostoglou (Зохиогч), Dimitra A. Lambropoulou (Зохиогч), Angeliki Katsarou (Зохиогч), Kostas Pantopoulos (Зохиогч), Dimitrios N. Bikiaris (Зохиогч)
• Формат: Ном
• Хэвлэсэн: MDPI AG, 2020-03-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...