Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

• Principais autores: Maria Lazaridou (Autor), Evi Christodoulou (Autor), Maria Nerantzaki (Autor), Margaritis Kostoglou (Autor), Dimitra A. Lambropoulou (Autor), Angeliki Katsarou (Autor), Kostas Pantopoulos (Autor), Dimitrios N. Bikiaris (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2020-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...