Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

• Главные авторы: Maria Lazaridou (Автор), Evi Christodoulou (Автор), Maria Nerantzaki (Автор), Margaritis Kostoglou (Автор), Dimitra A. Lambropoulou (Автор), Angeliki Katsarou (Автор), Kostas Pantopoulos (Автор), Dimitrios N. Bikiaris (Автор)
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• Опубликовано: MDPI AG, 2020-03-01T00:00:00Z.
• Предметы: article
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The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...