Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

• Váldodahkkit: Maria Lazaridou (Dahkki), Evi Christodoulou (Dahkki), Maria Nerantzaki (Dahkki), Margaritis Kostoglou (Dahkki), Dimitra A. Lambropoulou (Dahkki), Angeliki Katsarou (Dahkki), Kostas Pantopoulos (Dahkki), Dimitrios N. Bikiaris (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2020-03-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...