Formulation and In-Vitro Characterization of Chitosan-Nanoparticles Loaded with the Iron Chelator Deferoxamine Mesylate (DFO)

• Những tác giả chính: Maria Lazaridou (Tác giả), Evi Christodoulou (Tác giả), Maria Nerantzaki (Tác giả), Margaritis Kostoglou (Tác giả), Dimitra A. Lambropoulou (Tác giả), Angeliki Katsarou (Tác giả), Kostas Pantopoulos (Tác giả), Dimitrios N. Bikiaris (Tác giả)
• Định dạng: Sách
• Được phát hành: MDPI AG, 2020-03-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

The objective of this study was to develop chitosan (CS) nanoparticles (NPs) loaded with deferoxamine mesylate (DFO) for slow release of this iron-chelating drug. Drug nanoencapsulation was performed via ionic gelation of chitosan using sodium tripolyphosphate (TPP) as cross-linker. Nanoparticles wi...