Pharmacokinetics and Pharmacodynamics of T-Cell Bispecifics in the Tumour Interstitial Fluid

• Main Authors: Miro Julian Eigenmann (Author), Tine Veronica Karlsen (Author), Marek Wagner (Author), Olav Tenstad (Author), Tina Weinzierl (Author), Tanja Fauti (Author), Hans Peter Grimm (Author), Trude Skogstrand (Author), Christian Klein (Author), Johannes Sam (Author), Pablo Umana (Author), Marina Bacac (Author), Helge Wiig (Author), Antje-Christine Walz (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The goal of this study is to investigate the pharmacokinetics in plasma and tumour interstitial fluid of two T-cell bispecifics (TCBs) with different binding affinities to the tumour target and to assess the subsequent cytokine release in a tumour-bearing humanised mouse model. Pharmacokinetics (PK)...