Enantioselective Synthesis and Pharmacological Evaluation of Aza-CGP37157-Lipoic Acid Hybrids for the Treatment of Alzheimer's Disease

• Main Authors: Ángel Cores (Author), Patrycja Michalska (Author), José Miguel Pérez (Author), Enrique Crisman (Author), Clara Gómez (Author), Mercedes Villacampa (Author), José Carlos Menéndez (Author), Rafael León (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2022-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Hybrids based on an aza-analogue of CGP37157, a mitochondrial Na⁺/Ca²⁺ exchanger antagonist, and lipoic acid were obtained in order to combine in a single molecule the antioxidant and NRF2 induction properties of lipoic acid and the neuroprotective activ...