Enantioselective Synthesis and Pharmacological Evaluation of Aza-CGP37157-Lipoic Acid Hybrids for the Treatment of Alzheimer's Disease

• Главные авторы: Ángel Cores (Автор), Patrycja Michalska (Автор), José Miguel Pérez (Автор), Enrique Crisman (Автор), Clara Gómez (Автор), Mercedes Villacampa (Автор), José Carlos Menéndez (Автор), Rafael León (Автор)
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• Опубликовано: MDPI AG, 2022-01-01T00:00:00Z.
• Предметы: article
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Hybrids based on an aza-analogue of CGP37157, a mitochondrial Na⁺/Ca²⁺ exchanger antagonist, and lipoic acid were obtained in order to combine in a single molecule the antioxidant and NRF2 induction properties of lipoic acid and the neuroprotective activ...