Compartmental and COMSOL Multiphysics 3D Modeling of Drug Diffusion to the Vitreous Following the Administration of a Sustained-Release Drug Delivery System

• Main Authors: Emily Dosmar (Author), Gabrielle Vuotto (Author), Xingqi Su (Author), Emily Roberts (Author), Abigail Lannoy (Author), Garet J. Bailey (Author), William F. Mieler (Author), Jennifer J. Kang-Mieler (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of this study was to examine antibiotic drug transport from a hydrogel drug delivery system (DDS) using a computational model and a 3D model of the eye. Hydrogel DDSs loaded with vancomycin (VAN) were synthesized and release behavior was characterized in vitro. Four different compartment...