Improving the Angiogenic Potential of EPCs via Engineering with Synthetic Modified mRNAs

• Main Authors: Heidrun Steinle (Author), Sonia Golombek (Author), Andreas Behring (Author), Christian Schlensak (Author), Hans Peter Wendel (Author), Meltem Avci-Adali (Author)
• Format: Book
• Published: Elsevier, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The application of endothelial progenitor cells (EPCs) for the revascularization of ischemic tissues, such as after myocardial infarction, stroke, and acute limb ischemia, has a huge clinical potential. However, the low retention and engraftment of EPCs as well as the poor survival of migrated stem...