Ammonia inhibits energy metabolism in astrocytes in a rapid and glutamate dehydrogenase 2-dependent manner

Ammonia inhibits energy metabolism in astrocytes in a rapid and glutamate dehydrogenase 2-dependent manner

Astrocyte dysfunction is a primary factor in hepatic encephalopathy (HE) impairing neuronal activity under hyperammonemia. In particular, the early events causing ammonia-induced toxicity to astrocytes are not well understood. Using established cellular HE models, we show that mitochondria rapidly u...

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Main Authors: Leonie Drews (Author), Marcel Zimmermann (Author), Philipp Westhoff (Author), Dominik Brilhaus (Author), Rebecca E. Poss (Author), Laura Bergmann (Author), Constanze Wiek (Author), Peter Brenneisen (Author), Roland P. Piekorz (Author), Tabea Mettler-Altmann (Author), Andreas P. M. Weber (Author), Andreas S. Reichert (Author)
Format: Book
Published: The Company of Biologists, 2020-10-01T00:00:00Z.
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