Mutation Test in Korean Patients with Colorectal Carcinomas: A Methodological Comparison between Sanger Sequencing and a Real-Time PCR-Based Assay

• Main Authors: Sung Hak Lee (Author), Arthur Minwoo Chung (Author), Ahwon Lee (Author), Woo Jin Oh (Author), Yeong Jin Choi (Author), Youn-Soo Lee (Author), Eun Sun Jung (Author)
• Format: Book
• Published: Korean Society of Pathologists & the Korean Society for Cytopathology, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background Mutations in the KRAS gene have been identified in approximately 50% of colorectal cancers (CRCs). KRAS mutations are well established biomarkers in anti-epidermal growth factor receptor therapy. Therefore, assessment of KRAS mutations is needed in CRC patients to ensure appropriate treat...