Hallmarks of frailty and osteosarcopenia in prematurely aged PolgA(D257A/D257A) mice

• Main Authors: Ariane C. Scheuren (Author), Gommaar D'Hulst (Author), Gisela A. Kuhn (Author), Evi Masschelein (Author), Esther Wehrle (Author), Katrien De Bock (Author), Ralph Müller (Author)
• Format: Book
• Published: Wiley, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Frailty is a geriatric syndrome characterized by increased susceptibility to adverse health outcomes. One major determinant thereof is the gradual weakening of the musculoskeletal system and the associated osteosarcopenia. To improve our understanding of the underlying pathophysi...