Human Growth Hormone Delivery with a Microneedle Transdermal System: Preclinical Formulation, Stability, Delivery and PK of Therapeutically Relevant Doses

• Main Authors: Mahmoud Ameri (Author), Miryam Kadkhodayan (Author), Joe Nguyen (Author), Joseph A. Bravo (Author), Rebeca Su (Author), Kenneth Chan (Author), Ahmad Samiee (Author), Peter E. Daddona (Author)
• Format: Book
• Published: MDPI AG, 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study evaluated the feasibility of coating formulated recombinant human growth hormone (rhGH) on a titanium microneedle transdermal delivery system, Zosano Pharma (ZP)-hGH, and assessed preclinical patch delivery performance. Formulation rheology and surface activity were assessed by viscometry...