Repurposing Antimalarial Pyronaridine as a DNA Repair Inhibitor to Exploit the Full Potential of Gold-Nanoparticle-Mediated Radiation Response

• Main Authors: Nolan Jackson (Author), Abdulaziz Alhussan (Author), Kyle Bromma (Author), David Jay (Author), James C. Donnelly (Author), Frederick G. West (Author), Afsaneh Lavasanifar (Author), Michael Weinfeld (Author), Wayne Beckham (Author), Devika B. Chithrani (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Radiation therapy (RT) is frequently used to locally treat tumors. One of the major issues in RT is normal tissue toxicity; thus, it is necessary to limit dose escalation for enhanced local control in patients that have locally advanced tumors. Integrating radiosensitizing agents such as gold nanopa...