Vincristine-induced peripheral neuropathic pain and expression of transient receptor potential vanilloid 1 in rat

• Main Authors: Terumasa Chiba (Author), Yusuke Oka (Author), Hiroya Sashida (Author), Toshie Kanbe (Author), Kenji Abe (Author), Iku Utsunomiya (Author), Kyoji Taguchi (Author)
• Format: Book
• Published: Elsevier, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The clinical anti-cancer efficacy of vincristine is limited by the development of dose-dependent peripheral neuropathy. Up-regulation of transient receptor potential vanilloid 1 (TRPV1) is correlated with peripheral neuropathy following anti-cancer drug treatment. To analyze the contribution of TRPV...