Dual Angiotensin Receptor and Neprilysin Inhibitor Ameliorates Portal Hypertension in Portal Hypertensive Rats

• Main Authors: Shao-Jung Hsu (Author), Hui-Chun Huang (Author), Chiao-Lin Chuang (Author), Ching-Chih Chang (Author), Ming-Chih Hou (Author), Fa-Yauh Lee (Author), Shou-Dong Lee (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Portal hypertension is characterized by exaggerated activation of the renin-angiotensin-aldosterone axis. Natriuretic peptide system plays a counter-regulatory role, which is modulated by neprilysin. LCZ696 (sacubitril/valsartan) is a dual angiotensin receptor and neprilysin inhibitor. T...